A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions
Sabari Nath Neerukonda and Upendra Katneni. Pathogens 2020, 9(6), 426; Published: 29 May 2020. https://doi.org/10.3390/pathogens9060426
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials.
A Visual Guide to the SARS-CoV-2 Coronavirus
What scientists know about the inner workings of the pathogen that has infected the world. By Mark Fischetti, Veronica Falconieri Hays, Britt Glaunsinger, Jen Christiansen | . https://www.scientificamerican.com/article/a-visual-guide-to-the-sars-cov-2-coronavirus/
Inside the Coronavirus
What scientists know about the inner workings of the pathogen that has infected the world. Scientific American: https://www.scientificamerican.com/interactive/inside-the-coronavirus/